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Viagra and Sildenafil

Is Sildenafil the same as Viagra? Sildenafil is the name of the drug, the generic drug while Viagra is only one of its brand names. In some countries Sildenafil is sold under different names and you can get generic Sildenafil from countries where the patent on Viagra has expired. Also, Sildenafil is sometimes sold for erectile dysfunction under different names, depending on the manufacturer. However, in most western countries and in most cases, when you say Sildenafil you mean Viagra.

 

 

However, the name Viagra became a household name, thanks to the fact that Sildenafil was originally marketed under that name. Since then, more precisely in 2005, Sildenafil also became one of the FDA-approved treatments for a condition known as pulmonary arterial hypertension, which includes elevated blood pressure in the lungs, which can cause severe developments, some of which can be life-threatening. The brand name for Sildenafil when it is used for this purpose is Revatio. Therefore, it cannot be said that Sildenafil is solely Viagra. However, if you are taking Viagra, you are taking Sildenafil.

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Ever since it was developed and first introduced to the market, under the very name Viagra, Sildenafil has become and still is one of the most commonly sold erectile dysfunction drugs in the world. Up until the year 1998, when this happened, the only solution for this condition were different herbal supplements and different natural products that were not tested and that had no proven efficacy. In fact, in the cases in which these products worked and still work (because some people are still using them); the only benefits come from the placebo effect of these products.

However, in 1998, Sildenafil changed all of that. It was introduced to the market by Pfizer, the company that developed the medication. It was originally tested as a hypertension medication, but its efficacy for that condition was less than spectacular. However, it was observed that Sildenafil helps men with ED achieve erections and further development took a new course. Over the years, it has been perfected and in 1998, after a long approval process, Sildenafil became the first medication to be approved for erectile dysfunction. It was the first PDE5 inhibitor, meaning that its benefits for men with ED come from the fact that it inhibits the functioning of PDE5, an enzyme that directly causes erectile dysfunction.

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How does Viagra (Sildenafil) work?
This article in particular is meant to explain the mechanism of work of Viagra (Sildenafil), which is the mechanism of work of all the other approved ED medications on the market.

You may already be aware of the fact that Sildenafil is a PDE5 inhibitor. However, you may not be actually aware of what this means and how this makes it possible for men with ED to achieve erections. First of all, let’s cover the PDE5. PDE5 is an enzyme that we all have in our bodies, an enzyme that in fact causes erectile dysfunction in the large majority of cases. Namely, this enzyme affects another natural chemical in the body, the cGMP. cGMP is a chemical that gets released when a man gets aroused and when nitrous oxide is released due to arousal. cGMP makes the blood vessels in the genital region to relax and dilate, causing the blood to enter the sponge-like tissue in the penis, resulting in an erection. However, when PDE5 is present in increased quantities, it leads to the deterioration of cGMP, which results in the inability to achieve erections.

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As Sildenafil is a PDE5 inhibitor, it works by preventing the deterioration of cGMP, by inhibiting PDE5. This leads to an increase in levels of cGMP, causing the relaxation and the dilation of the necessary blood vessels, leading to a proper blood flow into the sponge-like tissue in the penis, which ultimately results in an erection.

This is, basically, the way in which Sildenafil works and as you can see, it is a medication with serious scientific background unlike natural products and herbal supplements that are only claimed to be effective at treating ED.